Improving HCLS AI reasoning with open-source agent skills
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AI agents on foundation models often misapply healthcare and life sciences decision frameworks, citing the right guideline but applying it incorrectly. This post shares 38 open-source agent skills across 11 HCLS domains that close this gap, with installation steps, three worked use cases, and a 410-prompt evaluation showing a 70-86% win rate.
AI agents built on foundation models (FMs) often misapply healthcare and life sciences (HCLS) decision frameworks, even when they’ve seen the guidelines in training and in the system prompt. Ask an agent to classify a TP53 missense variant using ACMG/AMP criteria. It will cite the correct framework but misapply evidence categories, skip population frequency thresholds, or hallucinate computational predictor scores. The model knows facts but lacks the structured reasoning procedures that domain…
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