Bridging Modalities on the Cortex: Surface-based MRI to PET Translation with a Diffusion Bridge

Cortical hypometabolism measured by Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is a highly sensitive biomarker for dementia diagnosis. However, high costs, radiation exposure, and limited accessibility constrain its clinical utility. While cross-modal synthesis from Magnetic Resonance Imaging (MRI) offers a promising alternative, existing volumetric generation methods do not explicitly account for the highly folded cortical geometry, where disease-related patterns predominantly reside. To address this, we introduce a novel surface-based diffusion bridge framework DB-SUiT for MRI-to-PET translation that operates natively on the cortical manifold. A conditional Spherical U-shaped vision Transformer (SUiT) is specifically designed to model the intricate cross-modal relationships while preserving surface topology. It combines spherical convolutional encoders for multi-scale surface feature extraction with bottleneck Transformers to capture long-range spatial dependencies, while incorporating demographic and subcortical conditions to refine the synthesis. Evaluated on two datasets, including subjects with different dementia types, DB-SUiT demonstrates high-fidelity synthesis that substantially outperforms other baselines. In automated dementia classification, synthesized PET surfaces improve performance over MRI by 14.2% and PET volumes by 11.3%, approaching the performance of real PET surfaces. In a blinded reader study, synthetic PET achieved 85.5% diagnostic accuracy, compared with 75.8% for MRI and 95.2% for real PET. This further demonstrates cross-cohort and cross-pathology generalization, as the model was evaluated without retraining on an external cohort that included a dementia subtype not represented during training. Our code is available at https://github.com/ai-med/DB-SUiT.

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Robotic foundation models are typically evaluated through costly closed-loop rollouts, which motivates cheap offline proxies for model capability. The Platonic Representation Hypothesis (PRH) suggests that as representations improve, different modalities such as vision and language converge toward a shared statistical model of reality. We ask whether motion trajectories form another such modality: as embodied models become more capable, should their sensory representations converge toward the structure of physical motion? To examine this, we propose Sensorimotor Alignment (S^2), a training-free offline metric that measures how well a model's sensory representation aligns with the geometry of physical motion. We find that S^2 correlates positively with downstream robot task success across embodied model families, making it a low-cost offline proxy for prioritizing models before closed-loop evaluation. S^2 can also identify promising vision-language model (VLM) backbones even before costly fine-tuning into vision-language-action models (VLAs). Beyond this correlation, S^2 offers representation-level explanations for phenomena observed in VLAs and world action models (WAMs). With S^2, we extend PRH to embodied models and make sensorimotor alignment empirically measurable, offering insight into why an embodied model succeeds beyond its closed-loop success rate.

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Test-time scaling has emerged as a key inference strategy for reasoning models, where a model generates a large number of candidate solutions in the hope of finding at least one correct solution. Running all candidate solutions to completion can be computationally demanding, so recent work prunes the candidate pool after generating only a short prefix, committing further computation only to the surviving candidates. Existing pruning strategies divide broadly into two categories: Quality-based methods assign a score to each partial solution and discard those predicted to ultimately lead to an incorrect final solution, while diversity-based methods select partial solutions that follow different reasoning trajectories and are therefore likely to cover different final solutions. The tension between these two objectives is an instance of exploration versus exploitation, yet little to no prior work on pruning exposes this trade-off directly, let alone optimizes it. In this paper, we introduce a pruning procedure that addresses this trade-off directly by optimizing pass@k over the selected solution pool. In particular, it chooses the pool to maximize the probability that at least one of its partial solutions, when continued to completion, yields a correct answer. Because this objective simultaneously rewards high-quality partial solutions and penalizes redundancy among them, quality and diversity are naturally balanced by the criterion itself rather than through separate ad-hoc design choices. On eight open-weight reasoning models, our method outperforms existing quality-based and diversity-based pruning strategies. The gains are particularly pronounced when the pruning procedure keeps a moderate number of partial solutions for continued generation, highlighting the value of directly balancing quality and diversity during pruning.

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Constructing accurate and computationally tractable approximation spaces is a fundamental task in scientific computing. Partially trainable neural networks bridge fixed random features and fully adaptive representations. This paper quantifies a phase transition pattern in approximation bounds and observes analogous behavior in training errors: a rapid but smooth initial improvement followed by diminishing returns, with a sharper transition under greater initialization mismatch. Under polynomial spectral decay with exponent α>1 and leverage compatibility, we establish a squared L_2 approximation rate {O}((κ_P(m/δ)/m)^α) for two-layer networks of width m and trainable proportion P, where κ_P=(P/κ_1^*+(1-P)/κ_0^*)^{-1}. The bound holds uniformly over the unit ball of a reproducing kernel Hilbert space (RKHS) with probability at least 1-δ. The constants κ_0^* and κ_1^* quantify the fixed and trainable groups' sampling mismatches relative to the target RKHS. For spherical biased-ReLU features in dimension d, we verify these assumptions with α=(d+2)/(d-1) and κ_0^*=4{2}τ(d+1)/d for initialization scale τ1, and κ_1^*=1 under ridge leverage sampling. For d=5 and τ=10, a trainable proportion of approximately 4.1\% captures 90\% of the reduction in the approximation bound from P=0 to P=1. A structured three-layer example illustrates how a few trainable first-layer neurons exploit fixed downstream blocks through nonlinear composition. Numerical experiments across diverse settings, including networks with up to 15 layers, exhibit similar phase transitions in training errors.

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