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arXiv AI Papers

Data-Efficient and Interpretable Classification of Circulating Tumor Cell Phenotypes in Microfluidic Devices via Deep Learning

Accurate classification of circulating tumor cell (CTC) phenotypes can provide valuable information for assessing metastatic potential. Label free microfluidic devices provide a hydrodynamic obstacle course that transforms subtle biophysical characteristics of CTCs, including size and deformability, into distinct kinematic trajectories. However, the highly nonlinear fluid structure interactions governing these trajectories make the inverse problem of inferring cellular phenotype from trajectory data analytically intractable. While deep neural networks (DNNs) have emerged as a powerful approach for addressing this inverse problem, their effectiveness is constrained by the limited availability of trajectory data and the lack of physical interpretability. To address these challenges, we propose an interpretable and data efficient DNN framework for trajectory based CTC classification. To mitigate the scarcity of data, we develop Subsequence (SubSeq), a targeted augmentation strategy that randomly extracts informative local trajectory segments during training to promote learning from localized patterns. We further apply Gradient Weighted Class Activation Mapping to identify the trajectory features and physical regions of the microfluidic device that drive model predictions. Experimental results demonstrate that SubSeq improves classification accuracy over the evaluated baseline and augmentation methods. Furthermore, interpretability analysis suggests that localized trajectory segments contain substantial biophysical information relevant to accurate classification. This provides justification for SubSeq and also highlights the redundancy of full-length trajectories. More broadly, the proposed framework views microfluidic geometries as physical encoders of cellular mechanical properties, providing mechanistic insights that may inform the future design of diagnostic devices.

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arXiv AI Papers

Policy Iteration with Human Feedback: Bringing Post-Training RL to In-context Learning

Generative pretraining established reusable task representations; later work on language-based task conditioning and in-context learning showed that a fixed model could adapt its behavior from instructions and demonstrations. Policy Iteration with Human Feedback (PIHF) builds on this development and the recurrent evaluate-and-improve structure of generalized policy iteration. PIHF uses a pretrained language model as its execution substrate and moves persistent revision to a versioned natural-language policy and tool set. A language-model critic and clinical expert review complete-panel reasoning and tool-use trajectories to localize recurrent failures and form candidate revisions; the expert may reinterpret the evidence and retains authority over admission and rollback, while Recall@1 and Recall@5 validate outcomes after candidate execution. Across cumulative ablations and ultra-rare-disease benchmarks, a PIHF-derived policy improved Recall@1 in one proprietary executor and three open-weight executors spanning 3 to 49 billion active parameters. Gains were 32.7 percentage points for GPT-5.4 and 31.1 points for Qwen3.6-35B, a difference of 1.7 points. These results support the feasibility of using pretrained language models as fixed-weight execution substrates for expert-guided policy development in rare-disease diagnosis.

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arXiv AI Papers

Diagnosing Dense Same-Class Attribute Misbinding in Large Vision-Language Models

Large vision-language models can recognize the objects and attributes in a crowded scene yet assign an attribute to the wrong same-class instance. Generic visual-question-answering accuracy marks the response as wrong, while object-hallucination metrics may regard both the object and attribute as image-supported; neither reveals the transfer. This study formalizes this blind spot as Dense Same-Class Attribute Misbinding (DSCAM) and presents InstaBind-Lite, a controlled benchmark that makes it directly measurable. Its 524 images contain 529 curated groups of 3-6 same-class entities, 1773 boxed instances, ordered neighbors, distinguishable color-like attributes, and four complementary question levels, yielding 9580 deterministically evaluated questions. Unlike existing protocols, source-instance annotations separate unsupported generation and recognition failure from an attribute copied from another visible entity. Binding-specific metrics further quantify transfer frequency, adjacency, ordinal distance, and intervention effects. Across five open-source and two commercial/API models, the open-source systems average 19.84% Misbinding Rate and the API systems 7.55%; these errors are hidden by aggregate accuracy. Among identifiable transfers, 80.70% and 81.51%, respectively, originate from adjacent instances. Localization and instance-first interventions help selected models but are not universal remedies. InstaBind-Lite therefore turns previously undifferentiated wrong answers into source-identifiable failure categories and tests a reliability dimension that conventional benchmarks cannot determine: whether a model knows not only what is visible, but which instance owns each attribute.

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arXiv AI Papers

Historical Backtesting for Scientific Question Discovery: A Protocol and Astronomy Pilot

Systems that generate scientific research questions are evaluated today by expert scores, LLM-as-judge ratings, or curated case studies -- all subjective, none falsifiable. We formalize historical backtesting as an alternative: a system generates questions from a corpus frozen at a historical cutoff, the questions are frozen before any access to later literature, and a temporally isolated future corpus then determines whether each question was subsequently answered, partially addressed, independently posed, or ignored, and whether its underlying premise was supported or refuted. The protocol is model-agnostic: any system that emits frozen questions can be scored. We release reproducible astronomy instances with temporally isolated corpora, frozen questions, auditable labels, four reference baselines, and a submission interface. Two findings result. First, evidence-structure-first generation outperforms LLM-only prompting: across a generator decomposition crossed with a four-cutoff stress test (2010-2024, 798 judged questions) whose last window postdates model training, LLM-only generation shows memorized relevance without specific foresight, while a generator using no model weights at all finds questions whose premises the future refutes in every era. Second, a seven-rater agreement study (two blinded human annotators, five judge models, 90 items) indicts the outcome taxonomy rather than the judge: two careful humans agree at kappa = 0.17, every judge model agrees with the professional annotator as well or better (0.17-0.26), and frontier models agree with one another at 0.60 -- certifying an LLM judge by model-model agreement would have overstated its reliability threefold. A prospective instance -- 200 questions frozen 2026-08-17, scored 2027-2030 -- is released so the central claims become contamination-free tests that time itself will grade.

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arXiv AI Papers

GoalEvolve: From Handcrafted Algorithm Priors to Goal-Driven Evolution of Physical Design Algorithms

Physical design algorithms operate within tightly coupled, multi-stage optimization flows, where stage-local gains may vanish or induce downstream degradation. Existing program-evolution frameworks often rely on stage-local objectives or undifferentiated multi-metric feedback, which neither guarantee better final results nor identify which unmet requirement should guide the next iteration. We present GoalEvolve, a goal-driven framework that makes physical design algorithm evolution accountable for the final quality of results (QoR) of the complete flow. Given a multi-objective QoR target region, GoalEvolve converts unmet requirements into normalized target gaps, identifies the dominant bottleneck, and uses stage-resolved checkpoint evidence to locate the responsible stage. An LLM-based Teacher then narrows the search to a relevant algorithmic decision and source region, while parallel Student agents implement and validate hypotheses through full-flow evaluation. Local effects, optimization debt, and downstream retention are retained as mechanism evidence for subsequent evolution. Across eight ASAP7 designs, GoalEvolve improves post-route TNS by 30.67% on average and reduces leakage and dynamic power by 21.18% and 9.42% versus default OpenROAD. Relative to commercial-tool goals, it closes 62.20% of the normalized power gap on power-dominant designs, surpasses the TNS goals on both timing-dominant designs, and closes 32.48% of the equal-weight timing-power gap on joint designs. Across all three designs evaluated against Codex goal mode under matched budgets, GoalEvolve further improves TNS by 26.46% while reducing leakage and dynamic power by 12.38% and 0.76%, respectively.

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arXiv AI Papers

The Ethical Decision Head: Operationalizing Normative Ethics in Autonomous Vehicles via Reinforcement Learning from Human Feedback

As autonomous vehicles (AVs) approach Level 4 and Level 5 operational capability [SAE International, 2018], their on- board decision systems must handle not only safety-critical locomotion but also their subsequent moral weight. This paper details the Ethical Decision Head (EDH), a deep re- inforcement learning (RL) framework that encodes ethical reasoning as a differentiable reward signal, enabling a pol- icy gradient agent to learn morally-aligned driving behavior in scenarios whose state representation is aligned with the CARLA simulation environment [Dosovitskiy et al., 2017]. Two normative frameworks are instantiated and evaluated: a Utilitarian framework minimizing total casualties and a Kan- tian framework enforcing course maintenance as a categori- cal imperative. The EDH is trained via Proximal Policy Op- timization (PPO) [Schulman et al., 2017] against a Bradley- Terry reward model [Bradley and Terry, 1952] learned from pairwise human preference annotations over 200 collision- imminent scenarios. Results reveal an asymmetry in the learnability of normative ethical frameworks under human su- pervision. The Kantian condition, which reduces to a con- stant prediction task under the codebook, serves as a pipeline control: it confirms training stability and rules out infrastruc- ture failure as an explanation for the utilitarian result. The Utilitarian agent learned something more unsettling: human raters rewarded self-sacrifice over casualty minimization, and the model learned that preference faithfully. This divergence between what humans prescribe in theory and what they re- ward in practice suggests that RLHF does not learn ethics as philosophers define it, but as humans live it.

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arXiv AI Papers

UniTAC: Universal Task-Aware Compression via Weighted Distortion Measures

Physical AI systems such as autonomous vehicles and robots rely on timely exchange of high-dimensional sensory signals under tight bandwidth, latency, and energy budgets. Because the task driving downstream decisions evolves over time, a task-specific codec is brittle and retraining one per task is infeasible in the field. We propose UniTAC, a single learned image codec spanning universal (task-agnostic) to task-specialized operation, re-targeted at runtime without retraining. The task is abstracted as a per-component importance vector, derived, e.g., from gradient attribution of any downstream model, and transmitted as low-overhead side information that conditions both encoder and decoder. Trained once over a broad, randomized family of such vectors against weighted-reconstruction distortion, UniTAC keeps a fixed backbone and a single human-viewable reconstruction whose fidelity is steered to the active task by swapping the injected vector. We analyze the underlying weighted rate-distortion problem, characterizing when a diagonal weighted distortion is task-consistent and how weights relate to task sensitivity. Guided by this, we design a Vision Transformer (ViT) codec whose token-level conditioning natively realizes this weight-driven code. On a localized task at 0.034 bpp, a single UniTAC model reaches 91.4% accuracy, only 1.9% below a task-based codec (93.3%) and above universal codecs (76.9%).

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arXiv AI Papers

Hide&Seek: Learning to Explain in an End-to-End Differentiable Network

Instance-wise feature selection is a valuable tool for interpreting labeled data and the predictions of black-box models. In contrast to global feature selection techniques, instance-wise methods dynamically identify important features for each instance. A growing number of methods learn a selector, which identifies important features, and a predictor, which uses these to make predictions. However, these pioneering methods face challenges including information leakage and lack of differentiability, which can slow training. In this paper, we present Hide&Seek, an end-to-end differentiable model for instance-wise feature selection. We jointly learn feature selection and prediction under a single objective without information leakage. Hide&Seek outperforms existing state-of-the-art models across a range of experiments and is fast to train. We achieve this by reformulating feature removal as a differentiable operation where instead of discretely removing features, we replace a proportion of each feature. Training is further stabilized via a parsimony-weight annealing framework.

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arXiv AI Papers

Learning-to-Transition for Large-scale and High-Order MIMO Detection

High-order multiple-input multiple-output (MIMO) detection requires efficient search over a large discrete symbol space while producing reliable soft information for channel decoding. This paper develops a learning-to-transition (L2T) framework that formulates MIMO detection as a stochastic sequence of complete-vector transitions. At each transition, a channel-coupled Transformer updates both the instance embedding and the sampling policy, while a blockwise autoregressive factorization captures inter-stream dependence with moderate sequential complexity. For hard-output detection, a transition network is applied recursively and trained through a residual-to-BER curriculum, which first learns the MIMO search geometry from the exact residual metric and then aligns the policy with transmitted-bit accuracy. For soft-output reception, the well-trained hard policy is cloned at the parameter level into every layer of an untied soft-input soft-output iterative detection and decoding (IDD) receiver. This tied-to-untied transfer preserves the learned zero-prior search dynamics while enabling layer- and round-specific specialization under decoder feedback. Within each IDD round, decoder priors tilt candidate generation according to Bayes' rule, and likelihood-weighted terminal hypotheses produce posterior and extrinsic log-likelihood ratios for LDPC decoding. A multi-stage training strategy further stabilizes the hard-to-soft transfer by progressively exposing the receiver to synthetic and in-loop decoder-generated priors.

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arXiv AI Papers

Split the Labor: Separating Evidence Interpretation from Decision Aggregation

Systems that ask a language model to reach a conclusion from many sources usually concatenate them into one prompt. This conflates two operations with different requirements. Interpreting a source rewards capacity and context. Combining interpretations rewards fixed arithmetic, comparability across instances, and the option to return nothing. Once separated, the design problem becomes the interface between them. We propose a four-field evidence tuple (hypothesis, reliability bucket, rationale, provenance) and show that fixing it determines both halves. The separation also reveals a failure mode in how such systems combine, which we call count-scale drift. Thresholding a sum of unnormalized weights is exactly posterior thresholding, but at an operating point that slides with the number of sources consulted. The slide grows with reader reliability. When source reliabilities differ, the vote rule and the posterior order instances differently, and no threshold reconciles them. Pooling calibrated log-likelihood ratios addresses both problems. The fix is arithmetic rather than architectural, and applies to a class of rules beyond language models: score-summing triage engines, diagnostic panels scored by counting positives, and additive multi-signal detectors. We then instantiate the principle twice on one longitudinal corpus, once after outcomes resolve and once before. The same partition helps in both, at different granularities: over reading in the first, over learning capacity in the second. There, a small sequence encoder on an easy auxiliary objective plus a tree ensemble carrying the censored survival loss reaches 0.921 AUPRC against 0.805 for a hand-crafted baseline. We separate what transfers from what must be re-estimated per domain, and state five predictions that would falsify the framework, three negative results, and which comparisons remain confounded.

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arXiv AI Papers

Rollplex: Cross-Phase GPU Spatial Sharing for Vision Language Model Post-Training

Vision-language models (VLMs) enable embodied agents to reason and act from visual observations and language instructions. Reinforcement learning (RL) post-training enhances these capabilities using task feedback, but current on-policy RL runtimes execute rollout, reference scoring, and actor training in strict serial phases. While effective for text-only RL, this phase-granular execution is wasteful for VLMs, where processing dense video inputs and prompt prefixes occupies a large fraction of each phase. Because prefix processing is independent of the generated response, it can be run alongside rollout decoding, which leaves GPU compute capacity underutilized, without breaking synchronous on-policy semantics. We present Rollplex, a runtime that decomposes the reference and training phase and moves the prefix computation into the rollout decode window. Realizing this schedule requires more than concurrent kernel launches: naive colocation of Qwen2.5-VL-32\,B requires roughly 165\,GiB per GPU, while rollout and training prefer different tensor-parallel (TP) degrees and weight layouts. Rollplex addresses these constraints with two mechanisms. Phase-aware memory management controls HBM residency according to producer--consumer lifetimes. Parallelism-aware weight sharing uses the same physical storage for layout-compatible tensors across distinct TP degrees and reconstructs only incompatible tensors, avoiding a complete second actor copy. On 32 H800 GPUs, Rollplex achieves 1.23--1.30speedup over serial colocation and 1.57--2.24over disaggregation under the same GPU budget, while preserving the synchronous RL update.

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NVIDIA AI Blog

Universitas Gadjah Mada, Indosat and NVIDIA Open Indonesia’s First University AI Center to Develop Local AI Talent

Indonesia is taking charge of its AI future. This week, the Ministry of Communication and Digital Affairs (Komdigi), Indosat Ooredoo Hutchison (Indosat or IOH), NVIDIA and Universitas Gadjah Mada (UGM) launched the UGM Indosat NVIDIA AI Technology Center (NVAITC) in Yogyakarta — the country’s first university-based AI technology center. Established under Indonesia’s AI Center of […]

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arXiv AI Papers

Approximate Muon with low-rank adapters

The Muon optimizer shows clear benefits versus alternatives when pretraining neural networks. However, it is used less frequently for parameter-efficient fine-tuning (PEFT). One potential reason is that the most common PEFT method, LoRA, does not naturally combine with Muon since it is not mathematically possible to orthogonalize the weight update given by a low-rank parameterization. In this paper, we address this issue by approximating the solution to a relaxed Muon objective in the low-rank setting via linearization and then least-squares. We provide an efficient implementation that uses matmul operations only, as opposed to more complex linear algebra decomposition routines. Our method, sMuon (small Muon), performs favourably across SFT and a ReLoRA pretraining experiment. While results are model- and eval-dependent, we find overall that using Muon for low-rank fine-tuning provides moderate performance improvements.

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arXiv AI Papers

Designing Reinforcement Learning for Diffusion Models: A Unified Path-Space View

Reinforcement learning (RL) post-training provides a direct way to align diffusion models with human preferences and task-specific rewards. However, current RL algorithms for diffusion models remain fragmented: reverse-trajectory methods rely on discretized likelihood ratios, whereas forward-matching methods train on reward-labeled noising versions of the rollout samples. This paper shows that these seemingly different losses arise from a single path-space principle. Starting from the regularized diffusion-RL objective, we use importance sampling between sampling SDEs to obtain an explicit policy-gradient estimator on trajectory space. The estimator contains the stochastic Itô integral underlying Flow-GRPO-type updates; we derive an equivalent variance-reduced value-gradient form that recovers the forward-matching structure of AWM and DiffusionNFT. This identifies the empirical gap between these method families as a variance-reduction effect rather than a difference in RL principle. The derivation yields a unified design space organized by value-gradient estimation, weight functions, and sampling choices. Within this space, we propose a multi-sample KDE value-gradient estimator that reuses rollout groups, together with scale-bounded weight families that retain stable existing recipes while excluding singular ones. Experiments on SD3.5-M and Qwen-Image models validate the variance-reduction explanation and show that the resulting recipe improves over prior diffusion-RL baselines.

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arXiv AI Papers

More Correct Mass, Worse Answers: Why Power Sampling Can Fail and How to Fix It

Power Sampling sharpens a language model's distribution over complete generation trajectories, offering a verifier-free way to improve reasoning at inference time. It also has the potential to serve as a general-purpose front end for a broad range of downstream sampling methods. However, we uncover a striking paradox: Power Sampling can drive more probability mass toward correct trajectories while degrading the downstream inference it is intended to enhance. Using self-consistency as a representative case, we observe accuracy drops of up to 18.5 percentage points across models and reasoning benchmarks. We trace this paradox to two mismatches. Dose mismatch arises because a fixed exponent induces drastically different amounts of distributional change across problems. Coverage mismatch arises because global sharpening concentrates mass on a narrow set of dominant paths: high pass@k, often interpreted as evidence of preserved diversity, can therefore coexist with the loss of broad reasoning-path support required for downstream aggregation, search, and selection. Guided by this diagnosis, we replace uniform trajectory exponentiation with a deformation-controlled, support-preserving Power target that calibrates sharpening across problems while limiting the suppression of moderate-probability paths. In a same-budget instantiation with weighted self-consistency, the repaired sampler reverses the losses caused by global Power and outperforms standard multi-sample inference across reasoning benchmarks.

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arXiv AI Papers

CytoBERT: A Foundation Model for Cytometry Data

Cytometry measures the complex characteristics of single cells (e.g., counts and protein expression of immune cells) and is widely used across immunological research and clinical settings. However, cytometry data is highly heterogeneous and unstandardized due to experimental protocols and the choice of measured features. While machine learning methods hold the potential to gain deeper insights into cell biology, these challenges make them difficult to apply and transfer across studies. Recent advances in foundation models can alleviate these issues, but corresponding approaches are still scarce in this field. To address this, we provide CytoBERT, a publicly available, open-source, open-weight foundation model for single-cell cytometry data with variable marker panels. CytoBERT is pretrained in a self-supervised manner on a large-scale cytometry corpus (15 human datasets with heterogeneous marker panels and more than 50 million cells) curated through marker standardization, enabling it to learn transferable inter-marker relationships within cells. Fine-tuning CytoBERT for sample-level classification demonstrates that transfer learning across heterogeneous cytometry datasets is feasible, providing a starting point for scalable, generalizable cytometry analysis. Code is available at GitHub.

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