Protein design is a search problem. Choose amino acids for an eight-residue protein sequence and more than 25 billion combinations are possible. Choose amino...
Mistral is collaborating with NVIDIA to develop a new generation of AI-native engineering workflows powered by NVIDIA accelerated computing.
OpenAI and Google Cloud are bringing frontier models and Codex workflows to Gemini’s Model Garden, available through Google Cloud Marketplace.
In this paper, we study quantile distributional policy evaluation, where the return distribution under a given policy is approximated by the quantile Bellman fixed point η_m. We investigate the statistical accuracy of estimating η_m across quantile resolutions under Wasserstein distances. Assuming access to a generative model, we construct a quantile fixed point estimator η_m^{(n)} from an empirical Markov decision process and establish non-asymptotic error bounds under Wasserstein distances. When reward densities are uniformly bounded away from zero, we obtain a root-n high-probability bound simultaneously over all resolutions m and all Wasserstein orders 1p. When reward densities vanish at the support endpoints, we show that continuity and endpoint monotonicity suffice to preserve the same resolution-independent rate for 1p2. For p>2, we establish a root-n bound with coefficient m^{1/2-1/p}, together with a slower, resolution-independent n^{-1/p} bound for every finite p>2. We further obtain resolution-independent W_consistency governed by the continuity modulus of reward quantile functions. To investigate the sharpness of these bounds, we characterize the exact local asymptotic minimax risk at each fixed resolution as the expected Wasserstein-coordinate norm of the efficient Gaussian limit and prove that our estimator attains it. We then examine the resolution dependence of this optimal local risk. A regular one-state instance has resolution-independent local risk constants, whereas a single endpoint-vanishing two-state instance exhibits growth of order m^{1/2-1/p}, up to logarithmic factors along a resolution subsequence, for every p>2.
The rapid expansion of the Internet of Things enables seamless collaboration among connected devices, making indoor localization a critical component of industrial automation. However, conventional localization techniques struggle in dynamic environments. These methods depend on extensive, frequent data collection and environment-specific calibration, limiting scalability, interoperability, and effective use of prior research while imposing significant energy penalties that hinder practical deployment. To address these challenges, we propose an energy-efficient transfer learning (TL) based approach for visible light communication based indoor localization. Our method leverages TL to tackle environmental variability, including lighting fluctuations and physical obstacles that typically degrade localization performance, while simultaneously reducing computational overhead and energy consumption compared to conventional approaches. We also introduce a novel model efficiency (ME) metric, designed to integrate localization accuracy, energy efficiency, data efficiency, and transfer gain into a single evaluative measure for comprehensive optimization. Evaluations on a real-world dataset collected from a BOSCH factory demonstrate that our model achieves a 47% improvement in localization accuracy compared to a conventional model that does not utilize TL, and achieves up to 67.5% ME with TL models, compared to only 10.4% in conventional models under high-noise conditions. These results underscore the potential of our approach to deliver a highly efficient and scalable indoor localization system suitable for energy-constrained industrial applications.
Graph neural networks (GNNs) are among the standard tools for molecular property prediction, but the atom-level explanations of their predictions are hard for medicinal chemists to act on. We propose a change of input representation rather than a new model: molecules are encoded as fragment-level graphs from BRICS decomposition, where each node is a synthetically meaningful fragment whose features are the element-wise sum of its atoms' features. Because only the representation changes, any message-passing GNN and any post-hoc attribution method produces explanations at the resolution of functional groups instead of single atoms. Across four architectures, four prediction tasks, and two explainers under scaffold splits, fragment-level encoding matches atom-level test accuracy on roughly five-fold smaller graphs. Integrated-Gradients attributions recover known pharmacophores above chance on two enzyme targets, namely BACE at 1.5 times the chance rate, and PTR1 at 3.2 times. A like-for-like comparison against an aggregated atom-level baseline shows that post-hoc aggregation is not a stable substitute: its BACE hit rate range both exceeds and falls below the fragment model's hit rate depending on two arbitrary aggregation choices, whereas fragment-level training yields a single convention-free attribution at no predictive cost. The code is available at: https://github.com/4D-Lab/frame
Despite the success of foundation models in image synthesis, achieving fine-grained spatial control remains a significant challenge, typically requiring auxiliary structural adapters or complex inference-time steering. While modern vision-language (VLM) text encoders possess the latent capacity to represent spatial coordinates, generative models often fail to leverage this information. We demonstrate that the signal-to-noise ratio (SNR) distribution is a critical determinant of spatial grounding in flow-matching models. Using a novel synthetic benchmark of geometric primitives, we isolate structural mechanics from textural complexity inherent in natural imagery and introduce a rigorous color-aware layout metric to quantify spatial fidelity. We show that training on a centered SNR distribution results in poor layout adherence (25.9%). Instead, we identify high-noise regimes as a "critical learning phase" for spatial grounding. Shifting the training focus toward these stages increases layout adherence to 80.8%, effectively reaching the 83.6% reconstruction ceiling of the underlying variational autoencoder. We find that the necessity for this shift scales with resolution and aspect ratio variance, and that the conservative noise schedules employed by models like FLUX.1 are insufficient for precise layout adherence. Finally, we show that these findings translate to real-world imagery via the COCO dataset (1.0 vs. 57.3 Average Precision), where state-of-the-art layout adherence is unlocked through distribution tuning alone, without architectural modifications.
Bayesian optimization (BO) is typically used only for problems where the underlying function is deemed "expensive" (e.g. in time or money), with the speed of the BO algorithm being of little importance. In the real world, however, problems span a continuous range of values, going from cheap to expensive. In this paper, we present BO algorithms through the lens of a speed-performance Pareto frontier: we compare BO against faster algorithms like CMA-ES, and highlight how certain regions of the Pareto frontier are currently empty. As a solution, we propose a new set of fast BO methods that exploit the linear structure in existing BO algorithms, for both continuous and combinatorial inputs (from ~10 to 6000+ dimensions). Our methods achieve performance similar to state-of-the-art BO, while being more than 10^2to 10^3faster, opening the field of BO to an entirely new class of problems.
Lambda is joining the AI ecosystem at NVIDIA GTC Berlin 2026 around a shared set of priorities: making AI safer, more secure, and more efficient to run at scale.
Using a near-census of 802,863 resolved markets listed on Polymarket between January 2023 and May 2026, and only information available at listing (the market's title and description, named resolution source, and contract metadata), we predict lifetime trading volume and whether settlement is later disputed. Contract information predicts trading volume well (out-of-sample R^2 = 0.747 for log volume), and most of the signal is interpretable: market topic provides the largest gain (+0.289 R^2 over a 0.220 contract-feature baseline), wording and resolution-rule design add smaller but measurable improvements (+0.027 combined), and neural text models add little beyond the interpretable features. This performance does not survive a period of platform change coinciding with a shift in listing formats: accuracy in predicting whether a market reaches \1,000 falls from AUC 0.940 under same-period evaluation to 0.577$ when training on past quarters and testing on later ones. The loss concentrates in markets whose question forms were absent from training (76.9% of test markets; on familiar forms the model still reaches 0.778), and a decomposition attributes more of it to a changed relationship between contract characteristics and demand than to an outdated mapping from text to features. Dispute predictors are more stable but less precise: launch-time features rank dispute risk far better than chance (AUC 0.78), yet at a 0.31% base rate precision is too low for case-by-case prediction (average precision 0.012), so the scores suit ranking groups of markets rather than forecasting individual disputes.
Many learning systems are performative: once deployed, their predictions change the data distribution on which future models are trained. In multi-agent settings, this feedback is routed through a network of interacting learners, so stability depends not only on the strength of performativity but also on who affects whom. We study repeated retraining in multi-agent performative prediction and identify a spectral threshold that separates stable learning from worst-case learning obstruction. Prior work often collapses cross-agent feedback into a scalar contraction constant, missing this network structure. We instead introduce the reflexivity matrix Γ, which records how strongly one agent's deployment can move another agent's best response, defined from per-agent gradient sensitivities and curvature parameters. The threshold occurs when the spectral radius of this matrix crosses one. Below the threshold, repeated retraining converges geometrically to a unique performatively stable equilibrium, with cumulative excess loss bounded uniformly in the time horizon. Above the threshold, we construct noisy supercritical instances in which every local-information learner incurs expected cumulative excess loss growing linearly for horizons up to order 1/(ρ(Γ)-1). Together, these results characterize the threshold behavior through upper and lower bounds and recover the single-agent scalar threshold from prior work as a special case.
We consider online prediction from experts, a fundamental problem in machine learning, under differential privacy constraints. Existing private algorithms achieve near-optimal regret {O}({T}), where T is the time horizon. However, this bound becomes suboptimal when L^, the cumulative loss of the best expert, is significantly less than T. In this work, we present the first differentially private algorithm with regret {O}({L^}), offering a substantial improvement in the low-loss regime. Our regret bound matches the non-private lower bound up to poly-logarithmic factors for constant privacy parameters, demonstrating that privacy incurs only a small cost in this setting. Our result assumes that the input sequence is oblivious, i.e., it is fixed in advance and independent of the algorithm's outputs. We also prove that an Ω({T}) regret is inevitable for adaptively generated inputs, even when L^= 0.
Graph-level out-of-distribution (OOD) generalization is critical for deploying graph neural networks in real-world applications where distribution shifts are inevitable. Existing approaches typically require class labels during representation learning to decide which substructures are predictive, limiting their applicability. We propose SCARCE, a label-free representation-learning framework that yields distribution-shift-robust graph representations from an environment partition of the training graphs alone, whether that partition comes from dataset metadata or, when none is available, from clustering a self-supervised embedding. Our method operates in two stages: (1) a variational graph autoencoder is warm-started for graph reconstruction; and (2) an adversarial confusion mechanism forces the encoder to produce representations from which a discriminator cannot distinguish environments, while preserving graph-reconstruction fidelity. We provide theoretical analysis showing that environment confusion contracts environment-discriminative directions in the representation space, which, under regularized downstream classifiers, is equivalent to imposing a stronger directional penalty on environment-associated features. This feature-reweighting mechanism reduces reliance on spurious correlations without erasing information, offering a label-free, continuous relaxation of last-layer reweighting methods. Experiments on a controlled synthetic datasets and the DrugOOD datasets show that SCARCE achieves state-of-the-art OOD generalization among label-free methods, using no class labels during representation learning.
At GTC Berlin, NVIDIA is showcasing its full lineup of local AI hardware. RTX Spark, which launched last week, powers personal agents on Windows PCs; DGX Spark supports developers building and scaling applications on Linux; and DGX Station serves enterprise teams running frontier workloads on Linux, with a Windows version arriving in December. Announcements include: […]
