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256documentos

18últimos 7 días

NVIDIA AI Blog

RTX Spark Ignites Global Celebration as New Windows PCs Arrive

NVIDIA RTX Spark laptops are now available, bringing NVIDIA Blackwell RTX graphics, up to 128GB of unified memory and the full NVIDIA AI platform to slim, premium Windows PCs. Starting at $2,399, laptops from ASUS, Dell, HP, Lenovo, Microsoft and MSI bring powerful local AI, content creation and gaming capabilities to a portable device, with […]

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arXiv AI Papers

Medical Fine-Tuning Reshapes, Not Reduces, Patient-Facing AI Risk: A Rubric-Based, LLM-Judge Evaluation Framework

Patient-facing medical question answering with large language models (LLMs) is moving from research demonstrations to production deployments, yet evaluation remains anchored on factual correctness. Factuality is necessary but not sufficient: a response can be factually grounded and still issue a directive that, if acted on, would harm the patient. We introduce a risk-sensitive evaluation framework that scores responses by the presence and severity of six categories of risk-bearing language (treatment directives, contraindications, dosage expressions, urgency-triage cues, high-alert medication mentions, and overconfident assertions), anchored on published clinical harm taxonomies. Severity is classified by a three-judge LLM ensemble. We apply this framework to six 7-9B instruction-tuned models, three general (Mistral-7B, Phi-3.5-mini, Llama-3.1-8B) and three medically adapted (BioMistral-7B, OpenBioLLM-Llama3-8B, Med42-Llama3-8B), on 200 real patient questions from the K-QA benchmark. Two findings emerge. First, ensemble risk-bearing language is statistically independent of factual hallucination rate (pooled Spearman ρ= -0.065, n = 300, 95% CI [-0.18, +0.05]; distance correlation = 0.10, independence test p = 0.24). Second, medical fine-tuning does not reduce aggregate risk but reshapes it: continued-pretraining adaptations (BioMistral, OpenBioLLM) consistently suppress high-alert medication mentions while amplifying overconfident assertions, whereas clinical instruction-tuning (Med42) suppresses dosing only, without amplifying overconfidence. Per-category Krippendorff α is fair to good for the four linguistically anchored categories (0.53-0.71) and low for the two clinical-judgment-dependent categories (0.19, 0.31), indicating where automatic safety evaluation is and is not yet reliable. We release the rubric, judge prompts, and evaluation code.

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Microsoft Research

Proof-based general-purpose computing with Magnetar

Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research .

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Microsoft Research

Simulating student learning for better AI tutoring

StudentSim is a research system for evaluating and improving AI tutoring tools before they are tested with learners. It models how individuals may engage with tutors, giving feedback to improve tutor performance across subjects like chess, writing, and mathematics. The post Simulating student learning for better AI tutoring appeared first on Microsoft Research .

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arXiv AI Papers

GUIDE: Computationally Augmented Consensus for Trustworthy Clinical Practice Guidelines

Maintaining up-to-date clinical practice guidelines (CPGs) is essential for evidence-based medicine, but rapid evidence growth and complex expert consensus formation limit timely updates. We developed GUIDE, a multi-agent copilot system for human-AI collaborative guideline generation and updating. GUIDE delegates labor-intensive tasks to specialized AI agents while preserving expert judgment and final arbitration. In 12 NICE ophthalmology datasets, GUIDE achieved 88.85% literature recall, 86.06% alignment in certainty-of-evidence ratings, and 91.67% recommendation agreement, requiring 162.17 minutes per dataset on average (28.68% human intervention). Performance remained stable across 20 additional datasets from cardiology, endocrinology, gastroenterology, and respiratory medicine. Ablation analysis showed that removing expert intervention reduced performance in judgment-intensive steps such as Risk-of-Bias assessment. In six post-cutoff datasets, GUIDE maintained robust end-to-end performance on unseen evidence. Prospective real-world validation showed that GUIDE reduced expert workload and produced more clinically acceptable recommendations than the original decade-old guideline (mean score, 3.73 vs. 1.53; agreement, 66.7% vs. 13.3%), with outcomes comparable to human-only updating (P = 0.588) but substantially less time and effort. GUIDE offers a practical framework for timely, trustworthy, expert-centric guideline development and validates computationally augmented consensus.

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